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目的:探讨肝癌诊断中甲胎蛋白异质体检测的价值分析。方法:选取我院2012年7月-2014年3月份期间的140例甲胎蛋白阳性血清样本,其中肝癌患者40例、肝硬化患者60例、肝炎患者20例、排除相关肝病者20例,对照各组之间的检测结果。结果:肝癌组的AFP-L3比值明显高于肝硬化组、肝炎组、排除相关肝病组(P<0.01)。结论:原发性的肝癌临床治疗和诊断可以用于AFP-L3比值作为分子标志物,对临床有辅助诊断和鉴别诊断的价值。
Objective: To explore the value analysis of alpha-fetoprotein heteroplasmy in the diagnosis of hepatocellular carcinoma. METHODS: A total of 140 AFP positive serum samples were collected from July 2012 to March 2014 in our hospital, including 40 patients with hepatocellular carcinoma, 60 patients with liver cirrhosis, 20 patients with hepatitis, and 20 patients with excluded liver diseases. Test results between groups. Results: The ratio of AFP-L3 in liver cancer group was significantly higher than that in liver cirrhosis group, hepatitis group, and related liver disease group (P<0.01). Conclusion: The clinical treatment and diagnosis of primary liver cancer can be used as the molecular marker of AFP-L3 ratio, and it is valuable for clinical diagnosis and differential diagnosis.