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目的:探讨神经生长因子(NGF)及受体P75在非黑素性皮肤癌中的表达情况。方法:用原位杂交的方法对15例鳞状细胞癌(SCC)、12例基底细胞癌(BCC)、13例正常上皮(NS)中NGF及受体P75 mRNA进行了检测。结果:与正常皮肤组织比较,NGF mRNA在基底细胞癌组织中的表达明显增高(t=30.06,P<0.01),在鳞状细胞癌组织中的表达明显下降(t=19.62,P<0.01),鳞状细胞癌组织与基底细胞癌组织相比差异有统计学意义(t=57.36,P<0.01)。P75mRNA在皮肤正常组、基底细胞癌组、鳞状细胞癌组中的表达呈逐渐降低趋势,组与组之间两两比较差异均有统计学意义:鳞状细胞癌组与正常皮肤组(t=42.69,P<0.01),基底细胞癌组与正常皮肤组(t=30.37,P<0.05),鳞状细胞癌组与基底细胞癌组(t=18.49,P<0.05)。结论:NGF及受体P75可能在非黑素性皮肤癌发生及浸润中起一定作用。
Objective: To investigate the expression of nerve growth factor (NGF) and receptor P75 in non-melanocytic skin cancer. Methods: The expressions of NGF and P75 mRNA in 15 cases of squamous cell carcinoma (SCC), 12 cases of basal cell carcinoma (BCC) and 13 cases of normal epithelium (NS) were detected by in situ hybridization. Results: Compared with normal skin tissue, the expression of NGF mRNA was significantly increased in basal cell carcinoma (t = 30.06, P <0.01), and significantly decreased in squamous cell carcinoma (t = 19.62, P <0.01) The difference between squamous cell carcinoma and basal cell carcinoma was statistically significant (t = 57.36, P <0.01). The expression of P75mRNA in normal skin, basal cell carcinoma and squamous cell carcinoma gradually decreased, and there was significant difference between the two groups (P <0.05) = 42.69, P <0.01), basal cell carcinoma group and normal skin group (t = 30.37, P <0.05), squamous cell carcinoma group and basal cell carcinoma group (t = 18.49, P <0.05). Conclusion: NGF and its receptor P75 may play a role in the pathogenesis and infiltration of non-melanocytic skin cancer.