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目的分析3例药物相互作用引起的药物不良反应。方法汇总整理2010~2014年我院上报的药物不良反应1003例,从中筛选出因药物相互作用导致的药物不良反应病例,并对其进行分析和再评价。结果共有3例因药物相互作用引起的药物不良反应。1例为环孢素与伏立康唑联用,导致环孢素血药浓度升高,出现肢体抖动;1例为螺内酯与地高辛联用,导致地高辛中毒;1例为华法林与莫西沙星、阿奇霉素联用,导致血尿。结论在评估患者病情确实需要联合用药对患者进行治疗时,应同时分析是否存在不良的药物相互作用,权衡利弊,为患者制定更加合理的药物治疗方案。
Objective To analyze the drug adverse reactions caused by three drug interactions. Methods A total of 1003 cases of adverse drug reactions reported in our hospital from 2010 to 2014 were collected, and the cases of adverse drug reactions caused by drug interactions were screened out and analyzed and re-evaluated. Results A total of 3 cases of drug adverse reactions due to drug interactions. 1 case of cyclosporine combined with voriconazole, resulting in cyclosporine blood concentration, limb jitter occurred; 1 case of spironolactone and digoxin combined, leading to digoxin poisoning; 1 case of warfarin and mo Xisha, azithromycin combined, leading to hematuria. Conclusions When assessing the patient’s condition does require a combination therapy for the treatment of patients, it should be analyzed at the same time whether there are adverse drug interactions, weighing the pros and cons, to develop a more rational drug treatment programs for patients.