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过去认为血清AKP主要从骨骼产生并从胆汁排泄,因此临床上常常把AKP的测定用于骨骼及胆道疾患的鉴别诊断。随着生物化学的进展,人们认识到人体许多脏器和组织中都含有AKP。骨中的成骨细胞、肝、小肠、肾及胎盘是血清AKP同功酶的主要来源。运用新的生物化学分析方法,把AKP同功酶电泳并与蛋白电泳对照测定,可以区分来自不同组织的血清AKP同功酶。正常成人血清中的AKP大部分是肝型,有些人有一小部分来自骨
In the past that serum AKP is mainly produced from the bones and excreted from the bile, so often the clinical application of AKP determination for the diagnosis of bone and biliary disorders. As biochemistry advances, it is recognized that many organs and tissues in the body contain AKP. Osteoblasts, liver, small intestine, kidney and placenta in bone are the main sources of serum AKP isozymes. Using a new biochemical analysis method, AKP isoenzyme electrophoresis and protein electrophoresis control determination, can be distinguished from different tissues of serum AKP isozyme. AKP in normal adult serum is mostly liver, and some people have a small fraction of bone