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作者在21条急性开胸犬上,以微米狭窄器造成冠状动脉左旋支不同程度的狭窄.分别在轻度狭窄和临界狭窄基础上,静脉给予潘生丁(0.56mg/kg,注射4min)。用创伤性方法检测用药前后左心室收缩功能的改变,轻度狭窄时,给予潘生丁后,左室舒张压降低22％,冠脉血流量、室内压最大上升速率及室内压最大下降速率有升高趋势,表明心功得到了改善。临界狭窄时,给予潘生丁后,在室舒张压升高55％,而冠脉血流量、左室收缩压、室内压最大上升速率和室内压最大下降速率分别下降25％,33％,37％和51％,表明心功进一步恶化。本实验可部分解释临床冠心病患者做潘生丁试验所表现的不同结果,并为临床合理使用潘生丁提供了新的依据。
In 21 acute thoracotomy dogs, the stenosis of left circumflex coronary artery was caused by micrometer stenosis, and dipyridamole (0.56 mg / kg, injection 4 min) was given intravenously on the basis of mild stenosis and critical stenosis respectively. Before and after treatment with a traumatic approach to detect changes in left ventricular systolic function, mild stenosis, given dipyridamole, left ventricular diastolic blood pressure decreased 22%, coronary blood flow, maximum rate of ventricular pressure and maximum rate of decline of indoor pressure increased The trend shows that heart work has improved. In the critical stenosis, diastolic blood pressure was increased by 55% after dipyridamole administration, while coronary blood flow, left ventricular systolic pressure, maximum rate of increase in ventricular pressure, and maximum rate of decrease in ventricular pressure decreased by 25%, 33%, 37% and 51%, indicating further deterioration of heart function. This experiment can partly explain the different results of the clinical trials of dipyridamole in patients with coronary heart disease and provide a new basis for the clinical rational use of dipyridamole.