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目的探讨联合检测血清天冬氨酸-天冬酰胺β羟化酶(ASPH)、甲胎蛋白(AFP)以及高尔基体糖蛋白73(GP73)对于原发性肝癌的诊断意义。方法分别检测50例原发性肝癌患者、50例肝炎肝硬化患者和50例健康人血清中AFP、GP73和ASPH的含量,分析ASPH联合AFP、GP73检测对原发性肝癌的诊断意义。结果肝炎肝硬化组和健康对照组AFP、GP73和ASPH含量明显低于原发性肝癌组,差异有统计学意义(P<0.05);单独检测AFP、GP73和ASPH对诊断原发性肝癌的灵敏度分别为76.00%、86.00%和80.00%,特异度分别为88.00%、98.00%、86.00%,准确度分别为82.00%、92.00%、87.00%;GP73灵敏度、特异度及准确度均为三项中最高。联合检测AFP、GP73和ASPH三项灵敏度为96.00%,特异度为98.00%,准确度为97.00%,均高于单项检测。结论联合检测AFP、GP73和ASPH可作为诊断原发性肝癌的重要指标,可提高早期原发性肝癌的诊断率。
Objective To investigate the diagnostic value of serum aspartate-asparagine β-hydroxylase (ASPH), alpha-fetoprotein (AFP) and glycoprotein 73 (GP73) in the diagnosis of primary liver cancer. Methods The levels of serum AFP, GP73 and ASPH in 50 patients with primary liver cancer, 50 patients with cirrhosis and 50 healthy individuals were detected by ELISA. The diagnostic value of ASPH combined with AFP and GP73 in the diagnosis of primary liver cancer was analyzed. Results The levels of AFP, GP73 and ASPH in hepatitis cirrhosis group and healthy control group were significantly lower than those in primary liver cancer group (P <0.05). The sensitivity of AFP, GP73 and ASPH alone in the diagnosis of primary liver cancer Respectively, the accuracy was respectively 82.00%, 92.00% and 87.00% respectively; the sensitivity, specificity and accuracy of GP73 were all in three highest. The combined detection of AFP, GP73 and ASPH was 96.00% with specificity of 98.00% and accuracy of 97.00%, all higher than single detection. Conclusion Combined detection of AFP, GP73 and ASPH can be used as an important index in the diagnosis of primary liver cancer and can improve the diagnosis rate of early stage primary liver cancer.