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检测 41例不同级别脑胶质瘤标本和 7例正常脑组织 P1 6 蛋白表达情况和 PCNA指数。结果 :实验组P1 6蛋白表达缺失 2 7例 ,占 6 5 .85 %。P1 6蛋白表达缺失率和 PCNA指数随脑胶质瘤恶性程度级别增高呈上升趋势(P<0 .0 5 )。 PCNA指数与 P1 6 蛋白表达具有明显相关性 (P<0 .0 1)。表明 P1 6 蛋白是脑胶质瘤细胞周期和肿瘤细胞增殖活性的重要调控因子
The expression of P1 6 protein and PCNA index in 41 cases of different grades of glioma and 7 normal brain tissues were detected. Results: The expression of P1 6 protein in experimental group was 27 cases, accounting for 65.585%. The loss of P1 6 protein and PCNA index increased with the increase of malignant degree of glioma (P <0.05). There was a significant correlation between PCNA index and P1 6 protein expression (P <0.01). The results showed that P1 6 protein is an important regulator of glioma cell cycle and tumor cell proliferation activity