【摘 要】
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Bcl-3 is an established oncogene in diverse malignant tumors.In this study,we investigated a dual role of Bcl-3 in BL1-subtype triple-negative breast cancer (TN
【机 构】
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Key Laboratory of Stem Cell Biology, Shanghai Jiao Tong University School of Medicine(SJTUSM)& Shang
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Bcl-3 is an established oncogene in diverse malignant tumors.In this study,we investigated a dual role of Bcl-3 in BL1-subtype triple-negative breast cancer (TNBC).The BL1-subtype TNBC is featured by increasing cell cycle gene expression and the highest sensitivity to chemotherapy among all subtypes.Bcl-3 is associated with a better prognosis in BL1 patients.Bcl-3 knockdown in BL1 cell MDA-MB-468 induces the inhibition of cell proliferation and the G1/S transition arrest by promoting p27 and reducing the expressions of c-Myc and skp2 at mRNA and protein levels.Meanwhile,Bcl-3 enhances the sensitivity of MDA-MB-468 to chemotherapeutics ABX and PTX.Furthermore,the regulation mechanisms are restricted to BL1 cell and do not occur in SUM159PT,a typical MSL subtype of TNBC cell.These data suggest that Bcl-3 may be a potential clinical biomarker for diagnosis,treatment,and prognosis of patients with BL1-subtype TNBC.
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