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Dear Editor:The emergence of multidrug-resistant tuberculosis(MDR-TB)is bringing new challenges.MDR-TB is caused by Mycobacterium tuberculosis(M.tuberculosis)that is resistant to isoniazid and rifampicin,with or without resistance to other anti-tuberculosis drugs.Approximately 450,000 people developed MDR-TB worldwide in 2012 and an estimated 170,000 people died from the disease~([1]).Bacterial burden is not strictly correlated with disease progression,and several hallmarks of severe tuberculosis suggest that insufficiently controlled
Dear Editor: The emergence of multidrug-resistant tuberculosis (MDR-TB) is bringing new challenges. MDR-TB is caused by Mycobacterium tuberculosis (M. tuberculosis) that is resistant to isoniazid and rifampicin, with or without resistance to other anti-tuberculosis drugs.Approximately 450,000 people developed MDR-TB worldwide in 2012 and an estimated 170,000 people died from the disease ~ ([1]). Bacterial burden is not strictly correlated with disease progression, and several hallmarks of severe tuberculosis suggest that insufficiently controlled