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目的:研究我国西北汉族人群基质金属蛋白酶-9(matrix metalloproteinase 9,MMP-9)启动子基因单核苷酸多态-1562(C→T)与贲门癌、胃癌发生风险的关系。方法:以PCR-RFLP方法检测170例贲门癌、胃癌患者和200例正常对照者MMP-9-1562(C→T)多态的基因型;比较不同基因型与贲门癌、胃癌发生风险的关系,并分析吸烟与基因的交互作用。结果:贲门癌、胃癌病例组和对照组MMP-9C/C、C/T、T/T基因型分布频率分别为75.3%、22.4%、2.4%和77.5%、21.0%、1.5%,差异无统计学意义。病例组中T等位基因携带者与对照组相比,差异无统计学意义(“2=0.1938,P>0.01)。分层分析表明,吸烟者中T等位基因携带者与对照组相比,差异无统计学意义(”2=0.0811,P>0.01)。结论:我国西北汉族人群MMP-9启动子基因单核苷酸多态-1562(C→T)与贲门癌、胃癌的遗传易感性无明显关系。
OBJECTIVE: To study the association between the SNP of matrix metalloproteinase 9 (MMP-9) gene and the risk of gastric cardia cancer and gastric cardia cancer in the Han population of northwestern China. Methods: The genotypes of MMP-9-1562 (C → T) polymorphisms in 170 cases of gastric cardia cancer, gastric cancer and 200 normal controls were detected by PCR-RFLP. The relationship between different genotypes and cardia cancer and gastric cancer risk was compared , And analyze the interaction between smoking and genes. Results: The distribution frequencies of MMP-9C / C, C / T and T / T genotypes were 75.3%, 22.4%, 2.4% and 77.5%, 21.0% and 1.5% in gastric cardia cancer group, gastric cancer group and control group respectively Statistical significance. T allele carriers in the case group compared with the control group, the difference was not statistically significant ( “2 = 0.1938, P> 0.01) .Hierarchy analysis showed that smokers in the T allele carriers with the control group The difference was not statistically significant ( ”2 = 0.0811, P> 0.01). Conclusion: The SNP of MMP-9 gene (-1562 (C → T)) is not related to the genetic predisposition of gastric cardia cancer and gastric cancer in Northwest Han population of our country.