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目的对米非司酮配伍米索前列醇联合己烯雌酚治疗稽留流产进行临床分析,寻求安全、快捷、有效的流产方法。方法选择2011年12月—2012年12月收治的稽留流产患者120例,己烯雌酚5 mg/次口服,3次/d,连服3 d,同时于入院第1天晚上8点口服米非司酮50 mg,服药前后空腹2 h以上;第2天早晨8点和晚8点以同样方法口服同等剂量的米非司酮;第3天早晨8点于阴道后穹隆放置米索前列醇200μg,等待自然发动宫缩,观察胎物排出及宫缩情况。观察其效果及不良反应。结果流产成功97例,流产不全23例,无一例发生失血性休克、子宫破裂、宫颈裂伤、胎盘早剥、羊水栓塞等并发症。结论米非司酮配伍米索前列醇联合己烯雌酚治疗稽留流产是一种安全、简便、有效的终止妊娠方法,值得推广。
Objective To analyze the clinical efficacy of mifepristone combined with misoprostol and diethylstilbestrol in the treatment of missed abortion and to find a safe, quick and effective abortion method. Methods 120 patients with missed abortion, diethylstilbestrol 5 mg / orally, 3 times / d were enrolled in the study from December 2011 to December 2012. The patients were given oral administration for 3 days. At the same time, mifepristone 50 mg, fasting more than 2 h before and after taking the medicine; on the second day 8 o’clock in the morning and 8 o’clock in the evening, the same dose of mifepristone was orally administered; on the third day, misoprostol 200 μg Spontaneous contraction of the contractions, observation of fetal discharge and contractions. Observe the effect and adverse reaction. Results 97 cases of abortion success, 23 cases of incomplete abortion, no case of hemorrhagic shock, uterine rupture, cervical laceration, placental abruption, amniotic fluid embolism and other complications. Conclusion The combination of mifepristone and misoprostol plus diethylstilbestrol in abortion is a safe, simple and effective termination of pregnancy, which is worthy of promotion.