不同Cd2 + 离子浓度引起的人红细胞相对溶血率及临界溶血浓度CH0 已经测定 ,CH0 =2 .5× 10 - 4mol·L- 1。Cd2 + 跨膜进入人红细胞遵从一级动力学过程 ,其一级速率常数为 1.2× 10 - 2 h- 1。阴离子通道抑制剂DIDS及K+ ,Na+ ATPase抑制剂均可部分抑制人红细胞摄入Cd2 + ,Cl- 浓度和介质pH也影响Cd2 + 的细胞摄入 ,细胞摄入镉量随胞外Cd2 + 浓度增加线性增加。这些实验结果证明 ,人红细胞摄入Cd2 + 是涉及简单被动扩散、阴离子通道转运及主动传送的复杂过程 The relative hemolysis rate and the critical hemolytic concentration CH0 caused by different concentrations of Cd2 + have been determined, CH0 = 2.5 × 10 -4 mol·L -1. The first order kinetic process of Cd2 + transmembrane entry into human erythrocytes follows a first order rate constant of 1.2 × 10 -2 h -1. DIDS and K + and Na + ATPase inhibitors could partially inhibit the uptake of Cd2 + by human erythrocytes, and also affected the uptake of Cd2 + by the pH of media. The uptake of Cd by cells increased with the increase of extracellular Cd2 + concentration Linear increase. These experimental results demonstrate that the uptake of Cd2 + by human erythrocytes is a complex process involving simple passive diffusion, anion channel transport and active transport