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目的:探讨几种以免疫为主的非手术治疗方法对晚期复治肺癌的疗效及其临床意义。方法:102例晚期复治肺癌患者按主要治疗方法分单纯免疫治疗(A)、介入化疗(B)、雾化吸入免疫治疗(C)及热化疗(D)4组,观察4组的肿瘤缓解有效率、患者中位生存期及生存率。结果:A、B、C、D4组的肿瘤缓解有效率分别为:18.8%、45.4%、23.1%、20.0%;中位生存期分别为:6.09、7.35、5.46、10.24个月,B组及D组较高;2年以上生存率A组及D组较高,但4组间无统计差异。结论:单纯性全身免疫疗法肿瘤缓解率较低,微创介入化疗有较高的肿瘤缓解率,但并非一定可延长生存率。局部吸入性免疫疗法及热化疗有积极意义。
Objective: To investigate the efficacy and clinical significance of several non-surgical methods of immunization in the treatment of advanced lung cancer. Methods: A total of 102 patients with re-treatment of lung cancer underwent primary immunotherapy (A), interventional chemotherapy (B), nebulized immunotherapy (C) and thermo-chemotherapy (D) Efficacy, patient’s median survival and survival rate. Results: The effective rates of tumor remission in groups A, B, C and D4 were 18.8%, 45.4%, 23.1% and 20.0% respectively. The median survival time was 6.09, 7.35, 5.46 and 10.24 months respectively. Group D was higher; the survival rate of more than 2 years was higher in group A and group D, but there was no statistical difference among the four groups. Conclusions: Simple systemic immunotherapy has a low tumor response rate and minimally invasive interventional chemotherapy with high tumor response rate, but it may not necessarily prolong the survival rate. Local inhaled immunotherapy and thermochemotherapy have positive significance.