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目的探讨糖尿病患者血清胱氨酸蛋白酶抑制剂C(CysC)水平以及与早期肾脏损害的关系。方法采用免疫浊度法检测126例糖尿病患者及40例对照组血清CysC含量;采用苦味酸法检测上述对象的血清肌酐(Scr)含量。结果糖尿病组血清CysC及Scr水平均显著高于对照组(P<0.05),且年龄越大其CysC水平越高。结论血清CysC检测有助于了解糖尿病患者是否存在早期肾损害,对预防、治疗糖尿病肾病(DN)有重要意义。
Objective To investigate the relationship between serum cystatin C (CysC) and early renal damage in diabetic patients. Methods Serum CysC levels were measured by immunoturbidimetry in 126 patients with diabetes mellitus and 40 controls. The levels of serum creatinine (Scr) were measured by picric acid method. Results Serum levels of CysC and Scr in diabetic group were significantly higher than those in control group (P <0.05). The higher the CysC level was, the older the diabetic group. Conclusion Serum CysC can help to understand the existence of early renal damage in diabetic patients, which is of great significance for the prevention and treatment of diabetic nephropathy (DN).