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目的:研究深圳地区儿童过敏性疾病的季节性发病趋势和药物应用,促进临床合理用药,并及时指导医院药品储备。方法:应用我院信息系统数据库,统计2007～2009年在门诊就诊的四类典型的儿童过敏性疾病(过敏性鼻炎、哮喘、过敏性结膜炎、湿疹)的月患儿人次及全院抗组胺药年度用药频次,根据月均人数对构成比进行季节性分析,采用用药频次排序法,分析2007～2009年抗组胺药的用药情况。结果:儿童过敏性疾病的患病人数均有明显的季节性波动特征。我院抗组胺药的年总用药频次呈明显上升趋势,其中,以西替利嗪为代表的第二代抗组胺药使用频次2007年位居榜首,三年来构成比分别为37.10%、33.41%和24.17%。第一代抗组胺药酮替芬因价格低廉、疗效确切,其用药频率也始终保持在前3位,且以氯苯那敏为代表的第一代传统抗组胺药在低龄患儿中使用频次相对较高。结论:我院抗组胺药的临床用药基本合理,第二、三代新型抗组胺药已逐渐占主导地位。
OBJECTIVE: To study the seasonal trend and drug application of allergic diseases in children in Shenzhen, to promote the rational use of drugs in clinical practice and to timely guide the hospital’s drug reserves. Methods: The data of four types of typical childhood allergic diseases (allergic rhinitis, asthma, allergic conjunctivitis, eczema) in 2007-2009 outpatients and statistics of total hospital anti-group The annual frequency of drug use, according to the monthly average number of the composition of the seasonal analysis, the use of medication frequency ranking method to analyze the use of antihistamines 2007-2009. Results: The number of children with allergic diseases have obvious seasonal fluctuations. The total annual frequency of antihistamines in our hospital showed a significant upward trend. Among them, the second-generation antihistamines represented by cetirizine topped the list in 2007 with the proportions of 37.10% and 33.41 in the three years respectively % And 24.17%. The first generation of antihistamines ketotifen due to low prices, the exact effect of its frequency of medication has always remained in the top three, and chlorpheniramine represented the first generation of traditional antihistamines in young children The frequency of use is relatively high. Conclusion: The clinical use of antihistamines in our hospital is basically reasonable. The second and third generation antihistamines have gradually become dominant.