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[目的]观察扶正活血不同配伍组方对肝纤维化大鼠肝组织病理改善的影响。[方法]SD大鼠90只随机分成6组,正常对照组不造模,扶正活血中药治疗组按其不同配伍组方分为1号方、2号方、3号方,阳性对照组、模型组采用四氯化碳加橄榄油造模,通过对各组大鼠灌服不同药物及0.85%氯化钠溶液,观察其对大鼠肝组织病理学指标的影响。[结果]扶正活血1号方和2号方对大鼠肝纤维化程度分级有很好的改善作用,与模型组比较差异有统计学意义(P<0.01),与阳性对照组比较差异有统计学意义(P<0.05或P<0.01),而3号方改善作用不明显;对大鼠肝纤维化胶原沉积的改善,也以1号方和2号方作用明显,与模型组比较差异有统计学意义(P<0.01),与阳相对照组比较差异有统计学意义(P<0.05);3号方与模型组比较也有明显改善(P<0.01),而与阳性对照组比较差异无统计学意义(P>0.05)。[结论]扶正活血组方不同配伍组方对肝组织病理学指标均有一定改善作用,而以1号方和2号方更明显。
[Objective] To observe the effect of different prescriptions of Fuzhenghuoxue on hepatic pathological improvement in liver fibrosis rats. [Methods] Ninety Sprague-Dawley rats were randomly divided into 6 groups, while the normal control group was not model. The traditional Chinese medicine group of Fuzheng Huoxue Treatment group was divided into 1 group, 2 group, 3 group, positive control group, model Group CCl4 plus olive oil modeling, through the different groups of rats fed with different drugs and 0.85% sodium chloride solution to observe the rat liver histopathological parameters. [Results] Fuzheng Huoxue Decoction No.1 and Decoction 2 had a good effect on the grading of liver fibrosis in rats, which was significantly different from the model group (P <0.01), and there was statistical difference between the two groups (P <0.05 or P <0.01), while the improvement effect of No.3 was not obvious. The improvement of hepatic fibrosis collagen deposition in rats was also observed with the effect of No.1 and No.2 prescriptions, compared with the model group (P <0.01). There was a significant difference between the control group and the positive control group (P <0.05), and there was a significant improvement (P <0.01) between the 3rd and the model groups, but no significant difference with the positive control group Statistical significance (P> 0.05). [Conclusion] Different prescriptions of Fuzheng Huoxue prescription can improve hepatic histopathological parameters, but more obvious with No.1 and No.2 prescriptions.