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目的 :观察辛伐他汀治疗混合性高脂血症患者的疗效和耐受性。方法 :采用开放性、自身对比研究 ,对 1 2 3例混合性高脂血症患者给予辛伐他汀 1 0 mg,每晚一次口服 ,共治疗 6周。结果 :6周后 ,血清总胆固醇、低密度脂蛋白胆固醇均较治疗前明显下降 (分别降低 2 3.8%、2 9.5 % ,P<0 .0 5 ) ,血甘油三酯也显著降低 (平均降低 2 7.1 % ,P<0 .0 5 ) ,高密度脂蛋白胆固醇明显上升 (平均升高 2 3.6 % ,P<0 .0 5 )。未出现严重不良反应。结论 :辛伐他汀对混合性高脂血症患者疗效明显 ,耐受性好。
Objective: To observe the efficacy and tolerability of simvastatin in patients with mixed hyperlipidemia. Methods: In an open and self-controlled study, 123 cases of mixed hyperlipidemia were given simvastatin 10 mg orally once daily for 6 weeks. Results: Serum total cholesterol (LDL) and low density lipoprotein cholesterol (LDL-C) decreased significantly after 6 weeks (by 23.8% and 25.5%, respectively, P < 2 7.1%, P <0.05), HDL cholesterol was significantly increased (an average of 23.6%, P <0.05). No serious adverse reactions occurred. Conclusion: Simvastatin has obvious curative effect on patients with mixed hyperlipidemia and good tolerance.