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目的探讨口服华法林抗凝治疗慢性阻塞性肺疾病的疗效。方法采用病例对照研究将肺功能中度以上阻塞的40例患者分为治疗组和对照组,对照组按指南常规治疗,治疗组在对照组基础上加用华法林抗凝治疗,疗程为1年,观察比较治疗前后患者D-二聚体、咳嗽评分(CAT评分)、呼吸困难指数、肺功能、急性加重次数的变化情况。结果治疗组D-二聚体定量降低明显,CAT评分、呼吸困难指数、年急性加重次数、肺功能均较对照组改善明显(P<0.05)。结论长期口服小剂量华法林抗凝治疗能改善慢性阻塞性肺疾病患者咳嗽、呼吸困难症状,改善肺功能,延缓肺功能下降,减少急性发作次数。
Objective To investigate the efficacy of oral warfarin anticoagulation in the treatment of chronic obstructive pulmonary disease. Methods A case-control study was divided into treatment group and control group with 40 patients with moderate or severe pulmonary function obstruction. The control group was treated according to the guideline routinely. The treatment group was given warfarin anticoagulation therapy on the basis of the control group. The course of treatment was 1 year, The changes of D-dimer, cough score (CAT score), dyspnea index, pulmonary function and acute exacerbation were observed and compared before and after treatment. Results The D-dimer in the treatment group was significantly lower than that in the control group (P <0.05). CAT score, dyspnea index, the number of acute exacerbations and lung function were all significantly improved. Conclusion Long-term oral low-dose warfarin anticoagulant therapy can improve cough and dyspnea symptoms, improve lung function, delay pulmonary function decline and reduce the number of acute episodes in patients with chronic obstructive pulmonary disease.