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阿片受体结合分析法除要求有高活性的氚标记二氢吗啡外,还要有高纯度的阿片受体。阿片受体存在于脊椎动物神经末梢的突触后膜上,人、猴、大白鼠的脑,豚鼠回肠和小白鼠输精管等组织中都有存在,但无脊椎动物中则无。它在脑中各部位存在差异很大,呈明显的区域性分布,以扁桃体、中脑导水管周围灰质最多,丘脑、尾核次之,大脑皮层、小脑和脊髓含量少,尤以小脑最少,白质比灰质更少。这种区域性分布与内源性递质的分布有密切关系。
In addition to the high activity of tritiated dihydromorphine, opioid receptor binding assays require high-purity opioid receptors. Opioid receptors exist in the postsynaptic membrane of vertebrate nerve endings, and exist in human, monkey, rat brain, guinea pig ileum and mouse vas deferens, but not in invertebrates. It has significant differences in various parts of the brain, showing a clear regional distribution to the tonsils, midbrain around the aqueduct gray matter, followed by the thalamus, caudate nucleus, cerebral cortex, cerebellum and spinal cord less, especially in the cerebellum at least, White matter is less than gray matter. This regional distribution and the distribution of endogenous neurotransmitters are closely related.