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目的:探讨C-反应蛋白(CRP)在川崎病(KD)诊疗中的意义。方法:30例KD患儿采用丙种球蛋白、肠溶阿司匹林、潘生丁等药物进行治疗,观察治疗前后患儿的CRP、血小板(PLT)、白细胞(WBC)的变化。结果:治疗后患儿血清CRP含量、WBC总数较治疗前明显下降,差异有统计学意义(P<0.05~0.01),PLT计数无明显变化(P>0.05)。结论:KD早期血清CRP含量升高,治疗3~5 d内CRP含量迅速下降,与临床症状的恢复成正比,CRP对KD的诊疗有一定临床指导意义。
Objective: To investigate the significance of C-reactive protein (CRP) in diagnosis and treatment of Kawasaki disease (KD). Methods: Thirty patients with KD were treated with gamma globulin, enteric-coated aspirin and dipyridamole. The changes of CRP, platelet (PLT) and white blood cell (WBC) in children before and after treatment were observed. Results: After treatment, the serum levels of CRP and the total number of WBC in patients were significantly lower than those before treatment (P <0.05 ~ 0.01). There was no significant change in PLT count (P> 0.05). CONCLUSIONS: In the early stage of KD, the content of CRP is elevated, and the content of CRP in 3 ~ 5 d after treatment declines rapidly, which is directly proportional to the recovery of clinical symptoms. CRP has certain clinical significance in the diagnosis and treatment of KD.