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目的观察高频单药组方与灌肠结合常规西医治疗慢性肾衰竭(CRF)对患者免疫功能及血清炎性因子的影响。方法将208例CRF患者随机分为研究组和对照组各104例。对照组患者给予常规西医治疗,研究组患者给予中西医结合治疗。比较2组患者的免疫功能及血清CRP、IL-6及TNF-α指标的变化。结果治疗后2组CD+4、CD+4/CD+8、lg G、lg M的水平均高于治疗前,CD+8水平低于治疗前,且研究组CD+4、CD+4/CD+8水平高于对照组,差异均有统计学意义(P<0.05)。治疗后2组CD+8、lg G、lg M水平比较差异无统计学意义(P>0.05)。治疗后2组血清CRP、IL-6及TNF-α水平均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。结论高频单药组方与灌肠结合常规西医治疗CRF能有效调节患者的免疫功能,并控制血清炎性因子的水平,能改善患者的肾功能,值得推广应用。
Objective To observe the effects of high-frequency single-drug combined with enema and Western medicine on immune function and serum inflammatory factors in patients with chronic renal failure (CRF). Methods 208 patients with CRF were randomly divided into study group and control group of 104 cases. Control group of patients given conventional Western medicine, study group given Integrative Medicine. The immune function and serum CRP, IL-6 and TNF-α in two groups were compared. Results After treatment, the levels of CD + 4, CD 4 + CD 8, Ig G, and IgM in the two groups were significantly higher than those before treatment, while the levels of CD + 8 were lower than those before treatment. The levels of CD 4 + CD 4 + CD + 8 levels higher than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the levels of CD + 8, lg G and lg M between the two groups after treatment (P> 0.05). The serum levels of CRP, IL-6 and TNF-α in the two groups after treatment were lower than those before treatment, and the difference between the two groups was statistically significant (P <0.05). Conclusion The combination of high-frequency monotherapy with enema and conventional western medicine can effectively adjust the immune function, control the level of serum inflammatory cytokines, and improve renal function in patients. It is worth to be popularized and applied.