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Objective:To assess the association of the number ofin-vitro fertilization(IVF) cycles and the age at menopause.Methods:A total of65 women who underwentIVF treatment in the years 1992-1995 were included and a questionnaire was performed.Results:Thirty-two women had spontaneously become menopausal until follow-up evaluation.Women who had undergone≥6 IVF-cycles had entered menopause significantly earlier than those who had undergone≤5 cycles [(46.9±1.8) years,n=11vs.(49.9±2.9) years,n=21;P=0.03)].Conclusions:Our data demonstrate a link between increasing number ofIVF cycles and ovarian aging.A direct influence ofIVF stimulation, the quality of oocytes at the time ofIVF as well as genetic factors might contribute to this phenomenon.