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目的探讨儿童炎性肌纤维母细胞瘤(IMT)的临床病理特征和免疫组化表型。方法分析11例儿童炎性肌纤维母细胞瘤的镜下特征和免疫组化表达,并进行文献复习。结果本组男性5例,女性6例,主要发生于腹、臀、肾上腺、颈及会阴,临床症状与部位相关。组织学显示梭形纤维母细胞和肌纤维母细胞疏密混杂排列,有黏液样基质及炎性细胞浸润。免疫组化:肿瘤细胞vimentin、SMA(+),desmin、NSE和MSA大部分(+);5例ALK-1(+),2例CK(+);S-100蛋白和CD34(-)。结论儿童IMT是一种常见的良性肿瘤,复发少见,但有恶变潜能。
Objective To investigate the clinicopathological characteristics and immunohistochemical phenotype of childhood inflammatory myofibroblastic tumor (IMT). Methods 11 cases of children with inflammatory myofibromoblast tumor characteristics and immunohistochemical expression, and literature review. Results The group of 5 males and 6 females mainly occurred in the abdomen, buttocks, adrenal glands, neck and perineum. The clinical symptoms were related to the site. Histology showed that spindle-shaped fibroblasts and myofibroblasts were sparsely populated with mucous-like matrix and inflammatory cell infiltration. Immunohistochemistry: Most of tumor cells vimentin, SMA (+), desmin, NSE and MSA (+); 5 ALK-1 (+), 2 CK (+); S-100 protein and CD34 (-). Conclusion IMT in children is a common benign tumor with rare recurrence but malignant potential.