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观察缺血再灌注大鼠胃酸分泌的变化，以及甲氰咪呱和五肽胃泌素对缺血再灌注胃损伤的影响。结果表明：①缺血期及再灌注期胃酸分泌均明显低于缺血前（Ｐ＜０．０５）；②缺血前肌注甲氰咪呱明显降低缺血再灌注胃粘膜损伤（Ｐ＜０．０５）；③再灌注开始时注射甲氰咪呱明显加重胃粘膜损伤（Ｐ＜０．０５），而五肽胃泌素则对胃损伤具有明显的保护作用（Ｐ＜０．０５）。
To observe the changes of gastric acid secretion during ischemia-reperfusion in rats and the effects of cimetidine and pentagastrin on gastric injury induced by ischemia-reperfusion. The results showed that: (1) gastric acid secretion during ischemia and reperfusion was significantly lower than that before ischemia (P <0.05); ② premedicated intramuscular injection of cimetidine significantly reduced gastric mucosal injury after ischemia-reperfusion (P < 0.05). ③The injection of cimetidine at the beginning of reperfusion increased gastric mucosal injury significantly (P <0.05), while pentagastrin had a significant protective effect on gastric injury (P <0.05) .