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目的探讨黄连阿胶汤加减联合常规西药降糖方案治疗阴虚热盛型糖尿病的临床疗效。方法选取武汉市新洲区人民医院2014年2月—2016年2月收治的阴虚热盛型糖尿病患者86例,按照随机数字表法分为对照组和观察组,各43例。对照组患者给予常规西药降糖治疗方案,观察组患者在对照组基础上给予黄连阿胶汤治疗,两组患者均持续治疗14 d。观察比较两组患者的临床疗效,治疗前后空腹血糖、餐后2 h血糖、糖化血红蛋白、血脂指标(总胆固醇、三酰甘油、低密度脂蛋白胆固醇)及C反应蛋白水平。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前,两组患者空腹血糖、餐后2 h血糖及糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白胆固醇及C反应蛋白水平比较,差异无统计学意义(P<0.05);治疗后,观察组患者空腹血糖、餐后2 h血糖及糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白胆固醇及C反应蛋白水平低于对照组(P<0.05)。结论采用黄连阿胶汤加减联合常规西药降糖方案治疗阴虚热盛型糖尿病的临床疗效确切,可有效降低患者血糖、血脂,改善临床症状。
Objective To investigate the clinical efficacy of Huanglian gelatin soup in combination with conventional western medicine hypoglycemic regimen in the treatment of yin deficiency-heat-type diabetes mellitus. Methods Totally 86 cases of yin deficiency and heat-type diabetes admitted in Xinzhou District People’s Hospital of Wuhan from February 2014 to February 2016 were divided into control group and observation group according to random number table method, with 43 cases in each group. Patients in the control group were given routine western medicine hypoglycemic treatment program. Patients in the observation group were treated with berberine gelatin soup on the basis of the control group, and both groups were treated for 14 days. The clinical efficacy, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, blood lipid (total cholesterol, triglyceride, low density lipoprotein cholesterol) and C-reactive protein were observed and compared between the two groups before and after treatment. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). Before treatment, fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin, total cholesterol, triglyceride, low-density lipoprotein cholesterol and C-reactive protein were not significantly different between the two groups (P <0.05) The levels of fasting blood glucose, postprandial blood glucose and glycated hemoglobin, total cholesterol, triglyceride, low density lipoprotein cholesterol and C-reactive protein were lower in the observation group than those in the control group (P <0.05). Conclusion Huanglian gelatin soup combined with conventional western medicine hypoglycemic regimen for the treatment of yin deficiency heat Shengdang diabetes clinical efficacy is exact, can effectively reduce the blood sugar, blood lipids and improve clinical symptoms.