临床资料患者,女,39岁。主因面部麻木1年余,四肢无力半年,皮肤变硬3个月,于2008年3月来我科就诊。患者1年前无明显诱因出现右上唇皮肤麻木,伴烧灼感,3天后发展至整个右侧面部,半月后左侧面部亦受累,多次在当地医院按“面神经麻痹、 Clinical data, female, 39 years old. Mainly due to facial numbness more than 1 year, limb weakness for six months, the skin hardens for 3 months, in March 2008 to our department. Patient 1 year ago, no obvious incentive to appear the upper right lip skin numbness, with burning sensation, 3 days after the development to the entire right side of the face, half a month after the left side of the face is also affected, many times in the local hospital by ”facial paralysis,