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目的:观察银杏叶提取物对糖尿病患者血液流变学和微血管循环的影响,为银杏叶提取物治疗糖尿病提供一定的理论基础。方法:给予正常对照组和糖尿病患者舒血宁片(含银杏叶提取物9.6mg/片,口服治疗,每日3次,每次2片,8周后,均空腹抽血检测血液流变学各项指标和微血管形态。结果:治疗组空腹、餐后60min、餐后120min的血糖及胰岛素水平均有明显的下降;而对照组空腹、餐后60min、餐后120min的血糖及胰岛素水平均无明显变化,表明银杏叶提取物显著降低糖尿病患者血糖及胰岛素水平。对照组除血液流变学指标血小板聚集率从(86.29±28.09)%降到了(33.80±16.78)%,血沉从(45.18±9.21)mm/L降到了(20.80±9.04)mm/L(P<0.01),其他血液流变学指标和微循环障碍有改善趋势,但无统计学意义。103例糖尿病患者的血液流变学指标如全血粘度从(14.03±1.34)m Pa·s降到了(7.98±1.76)m Pa·s、纤维蛋白原从(4.42±0.71)g/L降低到了(3.21±0.65)g/L,血小板聚集率从(87.92±18.23)%降到了(39.08±17.64)%,血沉从(48.33±12.03)mm/L降到了(20.19±7.19)mm/L(P<0.01)。微血管形态如毛细血管袢的数目、袢长、袢顶宽、及血管张力等项无明显差异,但治疗后血管袢的排列、变异程度、血管张力、变异率及血流速度等项趋于正常的患者明显增多。结论:银杏叶提取物对糖尿病患者的血液流变学和微循环障碍有明显的改善作用。
Objective: To observe the effects of Ginkgo biloba extract on hemorrheology and microvascular circulation in diabetic patients, and to provide a theoretical basis for the treatment of diabetes mellitus by Ginkgo biloba extract. Methods: The normal control group and diabetic patients Shuxuening tablets (containing Ginkgo biloba extract 9.6mg / tablet, oral treatment, 3 times a day, every 2, 8 weeks, fasting blood were measured hemorheology Indicators and microvascular morphology.Results: The fasting, postprandial 60min, postprandial 120min blood glucose and insulin levels were significantly decreased; while the control group fasting, postprandial 60min, 120min postprandial blood glucose and insulin levels were The results showed that Ginkgo biloba extract significantly reduced blood glucose and insulin levels in diabetic patients, while the hemorrheological parameters decreased from (86.29 ± 28.09)% to (33.80 ± 16.78)% in the control group and from (45.18 ± 9.21) ) mm / L decreased to (20.80 ± 9.04) mm / L (P <0.01), and other hemorheology indexes and microcirculation disturbance had an improvement tendency, but there was no statistical significance.Among the 103 patients with diabetes, the indexes of hemorheology When the whole blood viscosity decreased from (14.03 ± 1.34) m Pa · s to (7.98 ± 1.76) m Pa · s, the fibrinogen decreased from (4.42 ± 0.71) g / L to (3.21 ± 0.65) g / L, Aggregation rate decreased from (87.92 ± 18.23)% to (39.08 ± 17.64)% and erythrocyte sedimentation rate decreased from (48.33 ± 12.03) mm / L to (20.19 ± 7.19) mm /L(P<0.01) .Microvascular morphology, such as the number of capillaries 袢, 袢 long, 袢 top width, and vascular tension and other items was no significant difference, but the arrangement of vascular 袢 after treatment, degree of variation, vascular tone, mutation rate and Blood flow velocity and other items tended to be normal in patients with significantly increased.Conclusion: Ginkgo biloba extract on diabetic patients with hemorheology and microcirculation improved significantly.