凋亡抑制蛋白(IAPs)是胎盘组织表达的一类抑制凋亡的蛋白家族,通过其共同的杆状病毒重复序列(BIR)结构域,结合活化的天冬氨酸特异性半胱氨酸蛋白酶(caspase),多方位阻断和调控caspase凋亡通路,发挥抑制凋亡的作用。同时其在胎盘组织中表达分布具有时间和空间的多样性,推测其可能与受精卵的正常着床、胎盘的生长发育、母体的免疫耐受等有关。综述IAPs生物学特性、在妊娠胎盘组织中的分布特点、及其可能的抑制凋亡机制与调控作用。 Apoptosis inhibitory proteins (IAPs) are a family of proteins that inhibit apoptosis expressed in placental tissue through their common baculovirus repeat (BIR) domains, binding to activated caspases (caspase), multi-directional blocking and regulation of caspase apoptosis pathway, play a role in the inhibition of apoptosis. At the same time, its expression and distribution in placenta tissue have time and space diversity, suggesting that it may be related to normal implantation of fertilized eggs, placental growth and development, maternal immune tolerance and so on. The biological characteristics of IAPs, their distribution in placenta of pregnancy and their potential mechanism of apoptosis and regulation were summarized.