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目的:观察慢性乙型肝炎患者经α-干扰素(IFN-α)抗病毒治疗前后血清白细胞介素-6(IL-6)水平的变化与乙肝病毒消长之间的关系。方法:收集治疗前后血清标本—20C保存,通过ELISA法同步检测并与正常人做对照。结果:治疗前病人组血清中IL-6水平均较正常组高,尤其IFN-α治疗有效应答组增高明显。经IFN-α治疗的有效应答组IL-6水平较治疗前明显下降。结论:IFN-α除本身有抑制病毒复制外,通过免疫调节对病毒复制影响也具有重要作用。
Objective: To observe the relationship between the changes of serum interleukin-6 (IL-6) levels and the growth and decline of hepatitis B virus (HBV) in patients with chronic hepatitis B before and after antiviral treatment with IFN-α. Methods: The serum samples before and after treatment were collected and stored at -20 ° C, detected by ELISA and compared with normal controls. Results: The level of IL-6 in serum of patients before treatment was higher than that of normal group, especially in effective response group of IFN-α. The level of IL-6 in the effective response group treated with IFN-α was significantly lower than that before treatment. Conclusion: IFN-α can play an important role in the replication of virus by immunomodulation in addition to inhibiting viral replication.