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氯霉素抑制造血功能为众所周知,但所致溶贫尚未被重视,现将2例报道如下: 例1:男,23岁。因伤寒于1986年6月27日住院,经10%葡萄糖加氯霉素1g静滴,5天后出现酱油色尿,病人自觉腰痛、乏力。查体:贫血貌,皮肤及巩膜轻度黄染,肝脾均可触及。血红细胞97万,血红蛋白2.5g%,白细胞15100,幼稚12%,杆状14%,中性46%,淋巴28%,网织红细胞6.4%,尿为酱油色,蛋白(++++),未见细胞及管型,骨髓提示增生性贫血。诊断氯霉素所致溶血性贫血。例2:男,10个月。因腹泻服一天氯霉素
Chloramphenicol inhibition of hematopoietic function is well known, but the result is not yet taken care of the poor, now 2 cases are reported as follows: Example 1: Male, 23 years old. Due to typhoid fever in June 27, 1986 hospitalized, 10g of glucose plus chloramphenicol 1g intravenous infusion, 5 days after soy sauce color urine, the patient consciously low back pain, fatigue. Physical examination: anemia appearance, skin and scleral mild yellow dye, liver and spleen can be touched. RBC 970000, hemoglobin 2.5g%, leukocyte 15100, naive 12%, rod 14%, neutral 46%, lymphatic 28%, reticulocyte 6.4%, urine is soy sauce color, protein (++++), No cells and tubular, bone marrow prompted hyperplastic anemia. Diagnosis of chloramphenicol-induced hemolytic anemia. Example 2: Male, 10 months. Day diarrhea due to diarrhea chloramphenicol