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目的探讨染色体着丝粒点（Ｃｄ）的变异与ＨｅＬａ瘤细胞染色体非整倍性畸变的关系。方法用Ｃｄ分析技术研究ＨｅＬａ细胞染色体Ｃｄ的变异。结果ＨｅＬａ细胞染色体Ｃｄ缺失率为２．１０％、Ｃｄ迟滞复制率为０．２３％；与正常人胚胎绒毛细胞染色体Ｃｄ相比较，ＨｅＬａ细胞Ｃｄ缺失显著升高，而Ｃｄ迟滞复制没有显著性差异。结论ＨｅＬａ细胞染色体非整倍性畸变可能主要源于Ｃｄ缺失，而Ｃｄ迟滞复制则为非主要的。
Objective To investigate the relationship between chromosome centromere (Cd) variation and chromosome aberration of HeLa aneuploidy. Methods The variation of chromosomal Cd in HeLa cells was studied by Cd analysis. Results The chromosomal Cd deletion rate was 2.10% in HeLa cells and the delayed replication rate of Cd was 0.23%. Compared with normal human chorionic villi chromosome Cd, the Cd deficiency in HeLa cells was significantly increased, while there was no significant difference in Cd lag duplication . Conclusion The chromosome aberration in HeLa cells may be mainly due to the deletion of Cd, while the delayed replication of Cd is not essential.