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家兔iv内毒素后,在体温升高的同时,血浆cAMP含量与cAMP/cGMP亦显著升高。羚龙清热液给家兔以5.4/g/kg直肠灌药,可以抑制内毒素的致热作用,在解热的同时也抑制血浆cAMP含量与cA/cG比值的升高。羚龙清热液无抗感染、抗内毒素中毒作用。因此,其解热机理可能与抑制体内cAMP含量升高有关。
After rabbits had iv endotoxin, plasma cAMP levels and cAMP/cGMP levels also increased significantly at elevated body temperature. The treatment of rabbits with anteukaryotic clearing fluid at a dose of 5.4/g/kg rectally inhibited the endotoxin’s pyrogenic effect. It also inhibited the increase of plasma cAMP and cA/cG ratios while antipyretic. There is no anti-infective and anti-endotoxin poisoning effect of the antelope dragon clearing fluid. Therefore, its antipyretic mechanism may be related to inhibition of cAMP levels in vivo.