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目的探讨甲状腺黏膜相关淋巴组织淋巴瘤(Mucosa-associated Lymphoid Tissue Lymphoma,MALT-L)的发病机制,临床病理特征,诊断方法及治疗方式。方法报道我科诊治的1例甲状腺MALT-L病例并对相关文献进行学习和总结。结果甲状腺MALT-L多在桥本甲状腺炎的基础上进展而来,临床罕见,多表现为甲状腺弥漫性肿大或单发/多发肿块,术前诊断困难,常需病理加免疫组化检查确诊,治疗上以局部治疗为主(手术或放疗)结合化疗的综合治疗。结论甲状腺MALT-L临床少见,早期诊断和治疗预后较好,应加强对此疾病的认识,以提高早期诊断率。
Objective To investigate the pathogenesis, clinicopathological features, diagnosis methods and treatment of mutated lymphoid tissue lymphoma (MALT-L). Methods One case of thyroid MALT-L was diagnosed and treated in our department. The related literature was studied and summarized. Results The thyroid MALT-L was developed on the basis of Hashimoto’s thyroiditis. It was rarely seen in clinical practice. It was characterized by diffuse thyroid enlargement or single/multiple lumps. Preoperative diagnosis was difficult, and it was often diagnosed by pathology plus immunohistochemical examination. , Therapeutic treatment based on local treatment (surgery or radiotherapy) combined with chemotherapy. Conclusion The thyroid MALT-L is rarely seen in clinical practice. The prognosis of early diagnosis and treatment is good. It is necessary to strengthen the understanding of this disease so as to improve the early diagnosis rate.