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为了探讨胆汁中胆固醇和胆红素共同沉淀成石的规律,本文对胆汁中胆固醇和胆红素含量进行相关性分析。观察胆红素的参数为:总胆红素量(TB)、直接胆红素量(CB)、游离胆红素量(UCB)和游离胆红素百分比(UCB％);而观察胆固醇系的参数为:胆固醇量(Ch)、磷脂量(PL)、总胆盐量(BS)及成石指数(LI)。结果在组间对照研究中发现致石胆汁(70例)中UCB％和LI呈明显负相关,而非致石胆汁(8例)中无此现象。在同组对照研究申发现,当致石胆汁逆转为非致石胆汁后,UCB％和LI间原存的负相关关系随之消失。作者提出“空格占位“论对此作出解释。
In order to explore the common bile cholesterol and bilirubin co-precipitation into stone, this bile cholesterol and bilirubin content correlation analysis. The parameters of bilirubin were: total bilirubin (TB), direct bilirubin (CB), free bilirubin (UCB) and free bilirubin (UCB%); Parameters: Cholesterol (Ch), Phospholipid (PL), Total Bile Salinity (BS) and Stone Index (LI). Results In the intergroup study, there was a clear negative correlation between UCB% and LI in stone-bile (70 cases), but not in stone-free bile (8 cases). In the same group of controlled trials, it was found that the negative correlation between UCB% and LI disappeared when stone-induced bile was reversed to non-stone-derived bile. The author put forward the “space occupying” theory to explain this.