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殊特的染色体重排常重复出现于某些骨髓增生性疾病中。慢性粒细胞白血病(CML)的 t(9;22),急性粒细胞白血病(AML)的 t(8;21)和急性早幼粒细胞白血病(APL)的 t(15;17)为此提供了最好的例证。继发性白血病也同非随机性染色体改变有关。接受烷化剂治疗的肿瘤和非肿瘤性患者,包括何杰金氏病、慢性淋巴细胞白血病(CLL)、卵巢癌和乳腺癌、多发性硬化甚
Distinct chromosomal rearrangements often appear in some myeloproliferative diseases. This is provided for t (9; 22) for chronic myeloid leukemia (CML), t (8; 21) for acute myeloid leukemia (AML) and t (15; 17) for acute promyelocytic leukemia (APL) The best example. Secondary leukemia is also associated with non-randomized chromosome changes. Tumor and non-neoplastic patients receiving alkylating agents, including Hodgkin’s disease, chronic lymphocytic leukemia (CLL), ovarian and breast cancer, multiple sclerosis