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目的探讨地衣芽胞杆菌活菌制剂对肝病患者肠源性内毒素血症的临床治疗作用。方法将45例肝病且具有肠源性内毒素血症的患者分为观察组和对照组,2组间在性别、年龄、病程、临床特点及血清内毒素水平方面差异无统计学意义,观察组在对照组的基础上加用地衣芽胞杆菌活菌制剂治疗,治疗3周后再次检测2组的血清内毒素水平,并进行统计学分析。结果治疗前2组血清内毒素水平分别为(67.15±29.22)和(65.61±28.17)pg/ml。差异无统计学意义(P>0.05)。治疗后2组血清内毒素水平分别为(30.84±15.56)和(56.79±27.01)pg/ml(P<0.05),差异有统计学意义。结论地衣芽胞杆菌活菌制剂对肝病患者肠源性内毒素血症有治疗作用。
Objective To investigate the clinical therapeutic effect of viable Bacillus licheniformis preparation on enterogenous endotoxemia in patients with liver disease. Methods 45 cases of liver disease with intestinal endotoxemia were divided into observation group and control group. There was no significant difference in gender, age, course of disease, clinical features and serum endotoxin between the two groups. The observation group On the basis of the control group, Bacillus licheniformis was added and treated. After 3 weeks of treatment, the levels of serum endotoxin in two groups were detected again and statistically analyzed. Results Serum endotoxin levels in the two groups before treatment were (67.15 ± 29.22) and (65.61 ± 28.17) pg / ml, respectively. The difference was not statistically significant (P> 0.05). After treatment, the levels of serum endotoxin in the two groups were (30.84 ± 15.56) and (56.79 ± 27.01) pg / ml, respectively (P <0.05), the difference was statistically significant. Conclusion Bacillus licheniformis preparation has a therapeutic effect on enterogenous endotoxemia in patients with liver diseases.