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目的 探讨检测血清脂蛋白(a)[Lp(a)Lipoprotein(a)]对肾病综合征的诊断及疗效观察中的价值。方法 采用单克隆双试剂免疫比浊法,对41例肾病综合征患者血清中的脂蛋白(a)[Lp(a)]检测,同时检测其血清中的肾功能、血脂等指标的含量。结果 肾病综合征患者的血清中脂蛋白(a)、尿素氮(Bun)、尿酸(μA)、胆固醇(CH)、肌酐(Cr)等指标均高于对照组(P<005);而二氧化碳结合力(CO2CP)、甘油三酯(TG)、高密度脂蛋白(HDLC)等指标与对照组比较无显著性差异(P>005)。结论 血清脂蛋白(α)的测定是肾病综合征的诊断、疗效观察、病情预后的重要指标。
Objective To investigate the value of serum lipoprotein (a) [Lp (a) Lipoprotein (a)] in the diagnosis and treatment of nephrotic syndrome. Methods Serum lipoprotein (a) [Lp (a)] was detected by monoclonal dual immunoturbidimetry in 41 patients with nephrotic syndrome. The serum levels of renal function and blood lipid were also determined. Results Serum lipoprotein (a), blood urea nitrogen (uA), cholesterol (CH), creatinine (Cr) and other indexes in patients with nephrotic syndrome were higher than those in the control group (P < CO2CP, TG and HDLC had no significant difference compared with the control group (P> 005). Conclusion The determination of serum lipoprotein (α) is an important indicator of nephrotic syndrome diagnosis, curative effect observation and disease prognosis.