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选用１３ 种抗菌药物对１８ 株肠道杆菌进行药敏试验、质粒检测并用传统及改良两种接合转移试验方法，以５ 株伤寒杆菌的不相容性 Ｃ群（ Ｉｎｃ Ｃ） Ｒ 质粒、６ 株大肠杆菌及２ 株鼠伤寒杆菌的 Ｒ 质粒作供体，研究其在肠道杆菌间的传递。结果显示， Ｒ 质粒能在４ 种肠道杆菌间互相传递，其中伤寒杆菌 Ｉｎｃ Ｃ 群 Ｒ 质粒能在这４ 种菌中稳定复制并表达耐药性。质粒的可传递性给阻断耐药性的传播和疾病的防治带来很大困难，单纯消除某个菌中的耐药质粒已难以奏效，正常菌群中庞大的耐药基因库是致病性耐药菌株流行的潜在危险；合理选择、控制抗生素的使用，降低“选择性压力”显得尤为重要。
Thirteen kinds of antibacterial drugs were selected to test the susceptibility of 18 strains of enterobacteria. Plasmids were detected by conventional and modified two methods of conjugation and transfer assay. Five strains of Inc Salmonella incompatibility C group (R) and 6 strains Escherichia coli and two Salmonella typhimurium R plasmids as donors to study its transmission in enterobacteriaceae. The results showed that the R plasmid can be transmitted between the four kinds of enterobacteriae, among them, the Salmonella typhi Inc C group R plasmid can stably replicate and express the drug resistance in the four kinds of bacteria. The transferability of plasmids to block the spread of drug resistance and disease prevention and control brought great difficulty, simply to eliminate a drug-resistant plasmids in the plasmid has been ineffective, the normal flora of the gene pool is a large drug-resistant The potential danger of the spread of sex-resistant strains; rational selection, control of the use of antibiotics, reduce the “selective pressure” is particularly important.