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RH基因族进化的特点是经历了两次大的复制事件,第一次是RH50和RH30基因的起源,第二次是产生RHCE和RHD基因,这两逻辑倒错的RH30基因均编码人类Rh血型抗原。从小鼠RH50和RH30以及短尾猴RH50获得的新的序列资料,作者比较这两种基因的进化率显示,RH50的进化较之RH30在反义位置上大约慢了2.6倍。这一结果提示RH50蛋白较RH30多肽在进行化过程中更加保守,同样也预示在物种方面相距遥远,如海绵体生物与人类前蛋白的功能性意义。估计RH50和RH30基因的复制事件发生在250—346百万年之间。此外,作者也估计在人类、黑猩猩和大猩猩的共同先祖中产生RHCE和RHD基因的复制事件大约发生在8.5+/-3.4百万年之前。
RH gene family evolution is characterized by two major replication events, the first is the origin of RH50 and RH30 genes, the second is the generation of RHCE and RHD genes, the two logically inverted RH30 genes encode human Rh blood group antigen. Comparing the new sequence data obtained from mouse RH50 and RH30 and from the cynomolgus RH50, the authors compared the evolution rates of these two genes showing that the RH50 evolution was about 2.6-fold slower than the RH30 in the antisense position. This result suggests that the RH50 protein is more conserved than the RH30 polypeptide during the process of progression. It also predicts a long way to go in terms of species, such as the functional significance of cavernous organisms and human preproteins. The RH50 and RH30 gene replication events were estimated to occur between 250-346 million years. In addition, the authors also estimated that the replication events that produce RHCE and RHD genes in the common ancestor of humans, chimpanzees and gorillas occurred approximately 8.5 +/- 3.4 million years ago.