环孢霉素A(Cyclosporin A)为目前最强的免疫抑制剂,它的应用极大地提高了器官移植的成功率,但其抑制排斥反应的效果取决于适当的血浓度,浓度过高可产生严重的不良反应如肾毒性,过低则达不到抑制排斥反应的目的,由于环孢霉素常与其他药物如抗菌药物合用,可能的药物相互作用将影响环孢霉素的血浓度,甚至产生严重的后果,本文拟对环孢霉素的药物相互作用作一介绍,供临床使用时参考。 1.环孢霉素和利福平(Rifampicin)的相互作用一位患白斑的60岁妇女使用环 Cyclosporin A is the strongest immunosuppressive agent at present. Its application greatly improves the success rate of organ transplantation. However, the effect of inhibiting the rejection depends on the appropriate blood concentration. Over-concentration can produce Serious adverse reactions, such as nephrotoxicity, are too low to achieve the goal of inhibiting rejection. Since cyclosporine is often used in combination with other drugs such as antimicrobials, possible drug interactions will affect the blood levels of cyclosporine or even Have serious consequences, this paper intends to introduce the drug interactions of cyclosporine, for clinical reference. 1. Cyclosporine and Rifampicin Interactions A 60-year-old woman with leukoplakia uses a ring