【《美国医学协会杂志》1987年6月】一种称为CS-514的药物,根据体外试验和动物试验,可通过抑制3-羟基-3-甲基戊二酸单酰辅酶 A 还原酶而显示有降胆固醇的强大作用。该药是 compactin 的代谢产物。最近,日本东京医院的医学家曾用 CS-514治疗了41例高胆固醇血症的病人,用双盲法进行试验,剂量有每日5、20或40mg 三种方案,共用4周。结果在5mg 组中,平均血清总胆固醇水平下降11.1%,20mg 和40mg 组则分别下降18.8%和25.3%。对于 [Journal of the American Medical Association, June 1987] A drug called CS-514, which inhibits 3-hydroxy-3-methylglutaryl-CoA reductase Shows a strong cholesterol-lowering effect. This medicine is a compactin metabolite. Recently, 41 patients with hypercholesterolemia were treated with CS-514 by Japanese Tokyo Hospital physicians. The double-blind method was used. The dosage was 5, 20 or 40 mg daily for 4 weeks. Results In the 5 mg group, mean serum total cholesterol levels decreased by 11.1%, while those in the 20 mg and 40 mg groups decreased by 18.8% and 25.3%, respectively. for