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患者女,64岁。左侧腹股沟赘生物6年。皮肤科情况:左侧腹股沟见一约4cm×3cm大小肉红色赘生物,呈菜花状隆起,边界清楚,有蒂,表面粗糙,湿润,质脆,赘生物周围有暗红色斑疹。皮损组织病理示:角化过度,伴角化不全,真皮乳头瘤样增生,表皮颗粒层及棘层上部见多量凹空细胞,棘层内见多量不典型增生的细胞,可见病理核分裂相。真皮浅层见少量淋巴细胞浸润。行HPV分型检查示:高危型HPV病毒51亚型。诊断:疣型外阴上皮内瘤变(VIN)。
Female patient, 64 years old. Left groin vegetation for 6 years. Dermatology: The left groin see a size of about 4cm × 3cm meat red vegetation, cauliflower-like uplift, clear boundary, pedunculated, rough surface, moist, crisp, vegetation dark red rash. Pathological lesions showed: hyperkeratosis, with malalignment, dermal papilloma-like hyperplasia, epidermis granular layer and the upper stratum see a large number of concave cells, stratum see a large number of atypical hyperplasia cells, visible pathological mitosis. See a small amount of dermal shallow lymphocyte infiltration. Line HPV type examination showed: high-risk HPV virus 51 subtypes. Diagnosis: Vulvar vulvar intraepithelial neoplasia (VIN).