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白细胞介素-2(IL-2)是一种强力的细胞素,可引起多种炎性反应,包括早期激活多核白细胞(PMN)和后期生成淋巴细胞素激活的杀伤细胞(LAK),后者可抑制肿瘤生长,从而使IL-2亦可用作癌肿的免疫治疗。已知IL-2的有效癌肿治疗剂量可引起以全身渗透性增高为特征的严重中毒。近期应用羊肺淋巴瘘的研究提示,滴注IL-2后2～3小时肺微血管渗透性增加,同时伴有血栓素(TXB_2)增加,LAK细胞并不参与早期中毒的发生机制。由于有效的淋巴细胞激活需要血浆保持高浓度IL-2,因此要
Interleukin-2 (IL-2) is a potent cytokine that causes a variety of inflammatory responses, including early activation of polymorphonuclear leukocytes (PMNs) and later generation of lymphokine-activated killer cells (LAKs), the latter Can inhibit tumor growth, so that IL-2 can also be used as a cancer immunotherapy. It is known that an effective dose of cancer therapy of IL-2 can cause severe poisoning characterized by increased systemic permeability. The recent application of sheep’s lung lymphatic fistula studies suggest that 2 to 3 hours after instillation of IL-2 increased pulmonary microvascular permeability, accompanied by increased thromboxane (TXB_2), LAK cells are not involved in the pathogenesis of early poisoning. Since effective lymphocyte activation requires plasma to maintain high concentrations of IL-2, it is desirable