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目的探讨阿片类药物对硬膜外罗哌卡因分娩镇痛半数有效浓度(effectiveconcentrationin50%patients,EC50)的影响。方法随机将60例产妇分为A组(单纯罗哌卡因)、B组(罗哌卡因+芬太尼)各30例,A组首例用0.1%罗哌卡因15ml,B组首例用0.1%罗哌卡因+2μg/ml芬太尼药液15ml,其后根据前一例产妇对高或低浓度罗哌卡因药液的反应,按0.01%的浓度差依次变动局麻药的浓度,产妇VAS≤1cm为有效。结果A组EC50为0.158%,B组EC50为0.119%,B组EC50显著低于A组(P<0.01)。结论2μg/ml芬太尼可以降低硬膜外罗哌卡因分娩镇痛的半数有效浓度。
Objective To investigate the effects of opioids on the effectiveconcentration in 50% patients (EC50) of epidural ropivacaine. Methods A total of 60 pregnant women were randomly divided into group A (ropivacaine alone) and group B (ropivacaine + fentanyl). The first group was treated with 0.1% ropivacaine 15ml and group B Cases with 0.1% ropivacaine + 2μg / ml fentanyl 15ml, then according to the previous case of maternal response to high or low concentrations of ropivacaine solution, according to the concentration difference of 0.01% in turn changes of local anesthetic Concentration, maternal VAS ≤ 1cm is valid. Results The EC50 of group A was 0.158%, and the EC50 of group B was 0.119%. The EC50 of group B was significantly lower than that of group A (P <0.01). Conclusions 2μg / ml fentanyl can reduce the effective concentration of epidural ropivacaine labor analgesia.