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[目的]探讨G3BP和VEGFR-3在大肠癌中的表达及其意义。[方法]选取60例经手术切除癌组织后的大肠癌病人分别选取癌组织和癌旁组织,应用Westernblot方法分别测定G3BP和VEGFR-3在癌组织和癌旁组织中的表达,分析其相关性。[结果]大肠癌组织中G3BP表达的阳性率为70.0%,癌旁组织中未检出G3BP表达;G3BP表达与大肠癌Dukes分期(P<0.05)、淋巴结转移(P<0.05)有显著性相关。大肠癌组织VEGFR-3阳性表达率为58.3%,明显高于癌旁组织VEGFR-3的阳性表达率18.2%(P<0.05);VEGFR-3表达与大肠癌患者的Dukes分期(P<0.05)、淋巴结转移(P<0.05)有显著相关性。G3BP和VEGFR-3在大肠癌组织中表达呈正相关(r=0.376,P<0.05)。[结论]大肠癌中G3BP和VEGFR-3存在明显的高表达,与患者Dukes分期、淋巴结转移关系密切,G3BP和VEGFR-3之间存在显著性相关。
[Objective] To investigate the expression of G3BP and VEGFR-3 in colorectal cancer and its significance. [Methods] Sixty cases of patients with colorectal cancer who underwent resection of the cancer tissues were selected for cancer tissues and pericarcinomatous tissues respectively. The expression of G3BP and VEGFR-3 in cancer tissues and adjacent tissues was detected by Western blot. The correlation was analyzed . [Results] The positive expression rate of G3BP in colorectal carcinoma was 70.0%, while the expression of G3BP was not detected in adjacent tissues. The expression of G3BP was significantly correlated with Dukes stage (P <0.05) and lymph node metastasis (P <0.05) . The positive rate of VEGFR-3 in colorectal cancer was 58.3%, which was significantly higher than that in adjacent non-cancerous tissues (18.2%, P <0.05). The expression of VEGFR-3 was correlated with Dukes stage in colorectal cancer (P < , Lymph node metastasis (P <0.05) had a significant correlation. The expression of G3BP and VEGFR-3 in colorectal cancer was positively correlated (r = 0.376, P <0.05). [Conclusion] The expression of G3BP and VEGFR-3 in colorectal cancer is obviously high, which is closely related to Dukes stage and lymph node metastasis. There is a significant correlation between G3BP and VEGFR-3.