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本文报告复方甲基叔丁醚—二甲亚砜乳剂对胆色素结石进行家犬体内溶石研究的结果。复方甲基叔丁醚—二甲亚砜乳剂经犬胆囊造瘘管或经皮肝穿胆囊插管途径灌注溶石,平均用63.30±9.86小时,胆色素结石大都被溶解,溶石率达76.83±5.16%,有效率达100%,明显优于GMOC/BA-EDTA 和复方桔皮油乳剂(P<0.01)。B 超检查证实其能有效地溶解胆色素结石。且灌注溶石前后,犬血 ALT、TB、BUN 无明显改变(P>0.05);病理检查示犬胆囊、胆管、十二指肠、肝、胰、肾组织无明显异常。作者认为,复方甲基叔丁醚—二甲亚砜乳剂在体内亦能有效地溶解胆色素结石;若灌注方法适当,对动物和人体可能是安全的。
This article reports the results of compound methyl tert-butyl ether-dimethylsulfoxide emulsion on biliary pigment stone in dogs. Compound methyl tert-butyl dimethyl ether-dimethyl sulfoxide emulsion through the canal or percutaneous transhepatic gallbladder catheterization of percutaneous lysis of stone, with an average of 63.30 ± 9.86 hours, the majority of bile pigment stones were dissolved, the dissolution rate of stone 76.83 ± 5.16%, the effective rate of 100%, significantly better than the GMOC / BA-EDTA and compound orange peel oil emulsion (P <0.01). B-ultrasound confirmed that it can effectively dissolve bile pigment stones. There was no significant change in ALT, TB and BUN in dogs’ blood before and after perfused with lysophors (P> 0.05). Pathological examination revealed no obvious abnormalities in gallbladder, bile duct, duodenum, liver, pancreas and kidney. The authors believe that the compound methyl tert-butyl ether - dimethyl sulfoxide emulsion in the body can effectively dissolve the bile pigment stones; if perfusion method is appropriate, animal and human may be safe.