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目的:探讨不同剂量α1 A肾上腺素受体阻滞剂坦洛新对男性精子影响及安全性。方法:80名受试者随机分为2组(A组和B组),按交叉给药的方式给予安慰剂和坦洛新(顿服剂量为0.4mg或0.8mg),评估每个受试者的射精情况,同时记录性欲改变和坦洛新的不良反应。结果:所有受试者均出现了不射精症现象;服用0.4mg的坦洛新后,有功能的精子密度及有功能的精子总数显著减少,未出现明显的不良反应。结论:α1 A肾上腺素能受体阻滞剂坦洛新有男性抗生育的效果,可作为安全、有效、可逆的男性节育药,发展前景好。
Objective: To investigate the effects and safety of tamsulosin on male sperm in different doses of α1A adrenergic receptor blocker. METHODS: Eighty subjects were randomly assigned to two groups (Groups A and B). Placebo and tamsulosin (Dayton dose 0.4 mg or 0.8 mg) were given in crossover fashion. Each subject Ejaculation, while recording changes in sexual desire and adverse reactions to tamsulosin. Results: All subjects showed no ejaculation symptoms. After taking 0.4 mg of tamsulosin, the functional sperm density and the total number of functional sperm decreased significantly with no apparent adverse reactions. Conclusion: α1A adrenergic receptor antagonist tamsulosin male antifertility effect, can be used as safe, effective and reversible male birth control medicine, the development of good prospects.