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[目的]探讨儿童慢性特发性血小板减少性紫癜(cITP)与幽门螺杆菌(HP)的关系,观察根除HP对儿童cITP的疗效。[方法]对cITP患儿进行13C尿素呼吸试验检测,将确诊HP感染的14例患儿随机分成研究组(9例)和对照组(5例)。研究组采用免疫治疗加根除HP治疗,而对照组只采用免疫治疗,比较两组治疗前以及治疗后d7、第1,2,3月血小板的数目和临床效果。[结果]66例cITP患儿中有HP感染14例(21.2%),研究组的9例中,其中7例成功根除HP(77.8%)。治疗后d7、第1,2,3月血小板的数目比较显示,研究组明显高于对照组(P﹤0.01)。临床效果比较显示研究组的疗效显著高于对照组(P﹤0.05)。[结论]本临床研究中,HP的感染率为21.2%,采用HP根除治疗的根除率为77.8%,根除HP治疗有助于HP感染的cITP患儿的血小板恢复,取得明显的临床效果。
[Objective] To investigate the relationship between chronic idiopathic thrombocytopenic purpura (cITP) and Helicobacter pylori (HP) in children and observe the curative effect of eradication of HP on cITP in children. [Methods] 13C urea breath test was performed on cITP children. Fourteen children diagnosed with HP infection were randomly divided into study group (n = 9) and control group (n = 5). In the study group, immunotherapy plus eradication of HP was used, while in the control group, only immunotherapy was used. The number of platelets and the clinical effect of the two groups before treatment and after d7, first, second and third month were compared. [Results] There were 14 HP infection cases (21.2%) in 66 cases of cITP children. Of the 9 cases in study group, 7 cases successfully eradicated HP (77.8%). The comparison of the number of platelets in the first, second, and third month after treatment with d7 showed that the study group was significantly higher than that of the control group (P <0.01). Clinical results show that the efficacy of the study group was significantly higher than the control group (P <0.05). [Conclusion] The infection rate of HP in this clinical study was 21.2%. The eradication rate with HP eradication therapy was 77.8%. Eradication of HP therapy could help platelet recovery of HP infected cITP children and achieve a significant clinical effect.