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为观察乙肝疫苗注射后两年人群免疫效果,我们在张家港市凤凰乡设立了乙肝疫苗接种观察点,凡SGPT 正常,HBsAg、抗-HBs、抗-HBc 阴性的15岁以下儿童列为观察对象,随机抽样分组,采用0、1、6月免疫程序,对免疫组用10μg 剂量免疫(北京生物制品研究所生产的乙肝疫苗),另设空白对照组。在免疫儿童首次接种乙肝疫苗后两年采血,用RIA 法定量测定抗-HBc,分别计算出每毫升血清含毫国际单位抗-HBs 浓度,凡被测血清>10mIu/ml 为抗-HBs 阳性。
In order to observe the immune effect of two years after hepatitis B vaccine injection, we set up a hepatitis B vaccination observation point in Phoenix Township, Zhangjiagang. All children under 15 years old with normal SGPT, HBsAg, anti-HBs and anti-HBc were considered as observation objects, Random sampling group, using 0, 1, 6 months of immunization program, the immune group with 10μg dose of immunization (Beijing Institute of Biological Hepatitis B vaccine), another set of blank control group. Blood samples were collected two years after the first vaccination of the immunized children and anti-HBc was measured by RIA. Anti-HBs concentrations were calculated in milliliters per milliliter of serum. All tested serums> 10mIu / ml were positive for anti-HBs.