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本研究旨在探讨螺旋酶抗原基因(HAGE)在急性髓系白血病(AML)和慢性髓系白血病(CML)中的表达状况和临床意义。应用实时定量PCR(RQ-PCR)方法检测AML和CML患者骨髓单个核细胞中HAGE cDNA的表达。结果表明:74例AML患者中11例(14.8%)存在HAGE过表达(117.12%-9842.70%,中位434.96%);HAGE过表达患者年龄显著高于HAGE阴性者(中位年龄分别为67和45岁,p=0.001)。HAGE表达在单核细胞亚型AML(M4和M5,7/20,35.0%)中明显高于其它亚型AML(4/54,7.4%)(p=0.007)。28例核型正常的AML患者中8例(28.6%)呈HAGE过表达,而40例核型异常的AML中仅3例(7.5%)存在HAGE表达(p=0.041)。9/26例(34.6%)CML患者存在HAGE过表达,加速期和急变期患者中HAGE表达率(4/4,100%)明显高于慢性期患者(5/22,22.7%)(p=0.008)。结论:HAGE cDNA表达与AML单核细胞亚型类别相关,且与CML疾病进展相关。
This study aimed to investigate the expression and clinical significance of helicase antigen gene (HAGE) in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). Real-time quantitative PCR (RQ-PCR) was used to detect the expression of HAGE cDNA in bone marrow mononuclear cells of AML and CML patients. The results showed that HAGE was over-expressed in 11 (14.8%) of 74 AML patients (117.12% -9842.70%, median 434.96%); patients with HAGE overexpression were significantly older than HAGE-negative patients (median age 67 and 45 years old, p = 0.001). HAGE expression was significantly higher in monocyte subtype AML (M4 and M5, 7/20, 35.0%) than in other subtypes AML (4/54, 7.4%) (p = 0.007). Eighty patients (28.6%) with normal karyotype were HAGE overexpressed, whereas only three patients (7.5%) with abnormal karyotype showed HAGE expression (p = 0.041). The HAGE overexpression was found in 9/26 cases (34.6%) of patients with CML. The rate of HAGE expression was significantly higher in patients with chronic phase and accelerated phase (4 / 4,100%) than in patients with chronic phase (5/22, 22.7%) (p = 0.008) . Conclusion: HAGE cDNA expression is related to AML monocyte subtypes and is associated with the progression of CML disease.